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IL-12 and IL-23/Th17 Axis in Systemic Lupus Erythematosus

IL-12 and IL-23/Th17 Axis in Systemic Lupus Erythematosus

Maddalena Larosa, Margherita Zen, Mariele Gatto, Diogo Jesus, Elisabetta Zanatta, Luca Iaccarino, Luis Inês, Andrea Doria

Exp Biol Med (Maywood). 2019 Jan;244(1):42-51.

PMID: 30664357

Abstract:

Our article is focused on emerging pathogenetic pathways in systemic lupus erythematosus (SLE). Notably, IL-12 and IL-23 have been described as emerging cytokines in SLE pathogenesis. We know that IL-23 stimulates Th17 cells to produce IL-17. We try to point out the importance of IL-23/Th17 axis in SLE and to focus on the interaction between this axis and IL-12. Ustekinumab, a fully human IgG1κ monoclonal antibody directed towards the p40 shared subunit of IL-12 and IL-23, has been recently investigated in SLE, suggesting a potential novel therapeutic strategy in SLE. To our knowledge, there are no reviews which simultaneously focus on IL-12 an IL-23/Th17 axis in SLE. Thus, we believe our work will be of interest to the readers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248650	IL-12 human			Price

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