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IL-13 Improves Beta-Cell Survival and Protects Against IL-1beta-induced Beta-Cell Death

IL-13 Improves Beta-Cell Survival and Protects Against IL-1beta-induced Beta-Cell Death

Sabine Rütti, Cédric Howald, Caroline Arous, Emmanouil Dermitzakis, Philippe A Halban, Karim Bouzakri

Mol Metab. 2015 Nov 17;5(2):122-131.

PMID: 26909320

Abstract:

Objectives:
IL-13 is a cytokine classically produced by anti-inflammatory T-helper-2 lymphocytes; it is decreased in the circulation of type 2 diabetic patients and impacts positively on liver and skeletal muscle. Although IL-13 can exert positive effects on beta-cell lines, its impact and mode of action on primary beta-cell function and survival remain largely unexplored.
Methods:
Beta-cells were cultured for 48 h in the presence of IL-13 alone or in combination with IL-1β or cytokine cocktail (IL-1β, IFNγ, TNFα).
Results:
IL-13 protected human and rat beta-cells against cytokine induced death. However, IL-13 was unable to protect from IL-1β impaired glucose stimulated insulin secretion and did not influence NFκB nuclear relocalization induced by IL-1β. IL-13 induced phosphorylation of Akt, increased IRS2 protein expression and counteracted the IL-1β induced regulation of several beta-cell stress response genes.
Conclusions:
The prosurvival effects of IL-13 thus appear to be mediated through IRS2/Akt signaling with NFκB independent regulation of gene expression. In addition to previously documented beneficial effects on insulin target tissues, these data suggest that IL-13 may be useful for treatment of type 2 diabetes by preserving beta-cell mass or slowing its rate of decline.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413351	IL-13 from rat			Price

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