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IL-17A Levels Increase in the Infarcted Region of the Left Ventricle in a Rat Model of Myocardial Infarction

IL-17A Levels Increase in the Infarcted Region of the Left Ventricle in a Rat Model of Myocardial Infarction

Ana María Ávalos, Felipe A Apablaza, Mariana Quiroz, Viviana Toledo, Juan Pedro Peña, Luis Michea, Carlos E Irarrázabal, Flavio A Carrión, Fernando E Figueroa

Biol Res. 2012;45(2):193-200.

PMID: 23096364

Abstract:

Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-β mRNA levels with no apparent change in IL-17 mRNA or protein levels in whole LV. Only TGF-β mRNA remained elevated at week 4 post-MI. However, further analysis revealed that IL-17A mRNA and protein levels as well as IL-6 and IL-23 mRNA were indeed increased in the infarcted region, though not in the remote non infarcted region of the LV, except for IL-23 mRNA. The increased expression of IL-17A and Th17-related cytokines in the infarcted region of LV, suggests that this proinflammatory pathway might play a role in early stages of post MI cardiac remodelling.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413365	IL-17A from rat			Price

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