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IL-6 and IL-20 as Potential Markers for Vitality of Skin Contusion

IL-6 and IL-20 as Potential Markers for Vitality of Skin Contusion

Ming-Yuan Ye, Di Xu, Jin-Cen Liu, Hao-Pin Lyu, Ye Xue, Jie-Tao He, Hong-Yan Huang, Kai-Kai Zhang, Xiao-Li Xie, Qi Wang

J Forensic Leg Med. 2018 Oct;59:8-12.

PMID: 30059828

Abstract:

The detection of vitality of wounds is very important in forensic practice. This study is performed using quantitative real-time reverse transcriptase polymerase chain reaction (RT-qPCR) in both mouse and human skin wounds for the application of IL-6 and IL-20 in order to differentiate intravital wounds from postmortem wounds. RT-qPCR analysis of contused mouse skin showed that increased IL-6 and IL-20 mRNA levels were found in comparison to intact skin tissues. The increased mRNA expressions of IL-6 and IL-20 were observed until 72 h after death in contused mouse skin, whereas there were no marked changes in these two cytokines in the postmortem contusion group. The alterations of IL-6 and IL-20 can also be detected in human skin wound samples. These finding suggest that mRNA levels of IL-6 and IL-20 might be used as potential markers for vital reaction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413379	IL-20 human			Price

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