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Imidazole Clubbed 1,3,4-oxadiazole Derivatives as Potential Antifungal Agents

Imidazole Clubbed 1,3,4-oxadiazole Derivatives as Potential Antifungal Agents

Mohmmad Younus Wani, Aijaz Ahmad, Rayees Ahmad Shiekh, Khalaf J Al-Ghamdi, Abilio J F N Sobral

Bioorg Med Chem. 2015 Aug 1;23(15):4172-80.

PMID: 26164624

Abstract:

A series of compounds in which 2-(4-ethyl-2-pyridyl)-1H-imidazole was clubbed with substituted 1,3,4-oxadiazole was synthesized and subjected to antifungal activity evaluation. In vitro assays indicated that several clubbed derivatives had excellent antifungal activity against different strains of laboratory and clinically isolated Candida species. Structural Activity Relationship (SAR) studies revealed that the presence and position of substituents on the phenyl ring of the 1,3,4-oxadiazole unit, guides the antifungal potential of the compounds, where compound 4b, 4c and 4g were found to be active against all the tested fungal strains. Impairment of ergosterol biosynthesis upon the concomitant treatment of 4b, 4c and 4g, revealed the possible mechanisms of antifungal action of these compounds. Inhibitors snugly fitting the active site of the target enzyme, as revealed by molecular docking studies, may well explain their excellent inhibitory activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS77911	2-(4-Ethyl-2-pyridyl)-1H-imidazole			Price

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