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Immune Response in Guinea Pigs to Two Different Lipid Conjugates of Bovine Serum Albumin

Immune Response in Guinea Pigs to Two Different Lipid Conjugates of Bovine Serum Albumin

S B Singh, S Leskowitz

J Immunol. 1978 Mar;120(3):734-8.

PMID: 632585

Abstract:

A lipid conjugate of BSA was made by coupling dodecylamine to the COOH groups of BSA (DA-BSA). Studies on the immunogenicity of this material and one made by coupling dodecanoic anhydride to NH2 groups (D-BSA) demonstrated that cell-mediated immunity could preferentially be generated by lipid conjugation to an antigen as measured by delayed skin reaction, invitro blast transformation, and antibody formation. DA-BSA was found superior by both in vivo and in vitro tests. Both the conjugates retained the ability to suppress delayed type hypersensitivity, but only DA-BSA retained the ability to elicit optimum skin reaction in a sensitized animal and to precipitate anti-BSA antibody.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP645669	Dodecanoic anhydride		645-66-9	Price

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