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Immunoglobulin-mediated Hypersensitivity in Response to Long-Term Treatment With Gonadorelin Hydrochloride (Factrel) in a Female Patient

Immunoglobulin-mediated Hypersensitivity in Response to Long-Term Treatment With Gonadorelin Hydrochloride (Factrel) in a Female Patient

W G Foster, J F Jarrell, J Dolovich, E V YoungLai

Am J Obstet Gynecol. 1989 Apr;160(4):979-83.

PMID: 2653043

Abstract:

Recently a patient with severe hypogonadotropic hypogonadism who was given luteinizing hormone-releasing hormone (Factrel) through an infusion pump developed a wheat-and-flare reaction at the sites of injection. Treatment with luteinizing hormone-releasing hormone was discontinued and the immune response was characterized. Skin testing by skin prick test was positive for luteinizing hormone-releasing hormone but negative for vehicle. Radioallergosorbent testing was performed with allergic (patient serum with an elevated serum immunoglobulin E concentration and allergic to inhalant allergens including ragweed pollen) and nonallergic controls. Radioallergosorbent testing was negative for luteinizing hormone-releasing hormone-reactive immunoglobulin E antibodies. Radioimmunoassay of serum of the allergic patient antibody to luteinizing hormone-releasing hormone was positive only for immunoglobulin E. Maximum binding occurred at a dilution of 1:10. Sera from nonallergic and unchallenged patients were negative. It is concluded that this patient developed hypersensitivity reactions caused by IgE antibody to luteinizing hormone-releasing hormone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP33515092	Gonadorelin hydrochloride		33515-09-2 (free base)	Price

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