Home
Resources
Publications
Immunomodulatory Activity in Vitro and in Vivo of Verbascose From Mung Beans (Phaseolus Aureus)

Immunomodulatory Activity in Vitro and in Vivo of Verbascose From Mung Beans (Phaseolus Aureus)

Zhuqing Dai, Di Su, Yun Zhang, Yi Sun, Bing Hu, Hong Ye, Saqib Jabbar, Xiaoxiong Zeng

J Agric Food Chem. 2014 Nov 5;62(44):10727-35.

PMID: 25317918

Abstract:

In the present study, the immunostimulatory activity of verbascose from mung beans (Phaseolus aureus) was evaluated by using in vitro cell models and in vivo animal models. The results of in vitro experiments showed that verbascose could enhance the ability of devouring neutral red of peritoneal macrophages and promote the release of nitric oxide and immune reactive molecules such as interleukin (IL)-6, IL-1β, interferon (IFN)-α, and IFN-γ. Treatment with verbascose at a dose of 200 μg/mL exhibited the best effects. For assay in vivo, administration of verbascose at a medium dose of 90 mg/kg body weight could significantly increase the index of spleen, activity of lysozyme in spleen and serum, hemolysin level in serum, and swelling rate of earlap in the delayed type of hypersensitivity (DTH) of immunosuppressed mice. All of the results suggested that verbascose had potent immunostimulatory activity and could be explored as a potential natural immunomodulatory agent in functional foods.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP546623	Verbascose		546-62-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: