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Immunoregulatory, Proliferative and Anti-Oxidant Effects of Nanocurcuminoids on Adipose-Derived Mesenchymal Stem Cells

Immunoregulatory, Proliferative and Anti-Oxidant Effects of Nanocurcuminoids on Adipose-Derived Mesenchymal Stem Cells

Forouzan Yousefi, Fahimeh Lavi Arab, Mahmoud Reza Jaafari, Maryam Rastin, Nafiseh Tabasi, Mahdi Hatamipour, Karim Nikkhah, Mahmoud Mahmoudi

EXCLI J. 2019 Jun 17;18:405-421.

PMID: 31338010

Abstract:

Curcuminoids are dietary complexes extracted from the seeds of Curcuma longa L. that contain curcumin, bisdemethoxycurcumin and desmethoxycurcumin. Curcuminoids are popular for their pleiotropic therapeutic functions, such as their anti-inflammatory and anti-oxidant effects. Nonetheless, their clinical use is associated with poor systemic bioavailability and insolubility. The nano-formulation of curcuminoids eliminates these shortcomings. In the present study, we explored immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells (AT-MSCs). Flow cytometry analysis and MTT assay were employed to explore the effects of nanocurcuminoids on the apoptosis and proliferation of adipose-derived MSCs (AT-MSCs). The anti-oxidant effect of nanocurcuminoids on AT-MSCs also was examined. The immune regulatory effect of nanocurcuminoids was evaluated by the flow cytometric measurement of the T regulatory (Treg) population. The expression of inflammatory and anti-inflammatory cytokines was quantified using real-time PCR. Our findings demonstrate that low concentrations of nanocurcuminoids are beneficial for MSC proliferation, protection of MSCs from apoptosis, reducing inflammatory cytokines and SOD activity. A high concentration of nanocurcuminoids increases the population of Tregs and elevates the expression of TGFβ and FOXP3 genes. The beneficial effects of nanocurcuminoids on AT-MSCs were mainly observed at low doses of nanocurcuminoids.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24939171	Desmethoxycurcumin		24939-17-1	Price

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