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Immunosuppressive Activity of 8-gingerol on Immune Responses in Mice

Immunosuppressive Activity of 8-gingerol on Immune Responses in Mice

Jing Lu, Shuang Guan, Xue Shen, Wenhui Qian, Guoren Huang, Xuming Deng, Guanghong Xie

Molecules. 2011 Mar 22;16(3):2636-45.

PMID: 21441866

Abstract:

8-gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only signiﬁcantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19+ B cells and CD3+ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-speciﬁc IgG, IgG1 and IgG2b levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23513088	[8]-Gingerol		23513-08-8	Price

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