Home
Resources
Publications
Implications of Tryptophan Photoproduct FICZ in Oxidative Stress and Terminal Differentiation of Keratinocytes

Implications of Tryptophan Photoproduct FICZ in Oxidative Stress and Terminal Differentiation of Keratinocytes

Masutaka Furue, Hiroshi Uchi, Chikage Mitoma, Akiko Hashimoto-Hachiya, Yuka Tanaka, Takamichi Ito, Gaku Tsuji

G Ital Dermatol Venereol. 2019 Feb;154(1):37-41.

PMID: 30035475

Abstract:

Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen species (ROS) and mediates photocarcinogenesis and photoaging. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct generated by UVB exposure. FICZ exhibits similar biological effects to UVB, including AHR ligation and ROS production. FICZ also acts as a potent photosensitizer for UVA and the production of ROS is synergistically augmented in the simultaneous presence of FICZ and UVA. In contrast, FICZ upregulates the expression of terminal differentiation molecules such as filaggrin and loricrin via AHR. In parallel with this, the administration of FICZ inhibits skin inflammation in a murine psoriasis and dermatitis model. In this article, we summarize the harmful and beneficial aspects of FICZ in skin pathology.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP172922917	FICZ		172922-91-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: