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[Improvement of Powder Flowability and Hygroscopicity of Traditional Chinese Medicine Extract by Surface Coating Modification Technology]

[Improvement of Powder Flowability and Hygroscopicity of Traditional Chinese Medicine Extract by Surface Coating Modification Technology]

Rong-Gui Zeng, Qie-Ying Jiang, Zheng-Gen Liao, Guo-Wei Zhao, Yun Luo, Juan Luo, Dan Lv

Zhongguo Zhong Yao Za Zhi. 2016 Jun;41(12):2245-2249.

PMID: 28901067

Abstract:

To study the improvement of powder flowability and hygroscopicity of traditional Chinese medicine extract by surface coating modification technology. The 1% hydrophobic silica nanoparticles were used as surface modifier, and andrographis extract powder was taken as a model drug. Three different techniques were used for coating model drugs, with angle of repose, compressibility, flat angle and cohesion as the comprehensive evaluation indexes for the powder flowability. The powder particle size and the size distribution were measured by Mastersizer 2000. FEI scanning electron microscope was used to observe the surface morphology and structure of the powder. The percentage of Si element on the powder surface was measured by energy dispersive spectrometer. The hygroscopicity of powder was determined by Chinese pharmacopoeia method. All of the three techniques can improve the flowability of powder extract. In particular, hygroscopicity of extract powder can also be improved by dispersion and then high-speed mixing, which can produce a higher percentage of Si element on the powder surface. The improvement principle may be correlated with a modifier adhered to the powder surface.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP90244841	Powdered andrographis extract		90244-84-1	Price

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