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Improving Nausea and Vomiting Post-Elipse Balloon: A Novel Single-Dose Regimen of 300 Mg Netupitant/0.5 Mg Palonosetron Hydrochloride

Improving Nausea and Vomiting Post-Elipse Balloon: A Novel Single-Dose Regimen of 300 Mg Netupitant/0.5 Mg Palonosetron Hydrochloride

R Ienca, C Giardiello, A Scozzarro, R Schiano di Cola, N Di Lorenzo, Girish Juneja, G Lopez, F Badiuddin

Obes Surg. 2019 Sep;29(9):2952-2956.

PMID: 31104280

Abstract:

Background:
Post intragastric balloon placement symptoms like nausea and vomiting have been the major cause of a high rate of early removal. Common therapy with ondansetron alone, or in combination, with prokinetic agents have been shown to have very little or no effect. Recently, an improved therapy based on aprepitant and ondansetron combination showed a significant improvement in symptoms management. Lack of aprepitant availability in several countries and patients difficulties to follow the right prescription convinced us to explore other pharmacological options.
Objective:
Evaluate safety and efficacy of a netupitant and palonosetron-combined drug and to reduce and control post Elipse® placement symptoms METHODS: Between January and March 2018, 30 patients (9 male, 21 female), (mean weight 97.8 and mean BMI 34.7), underwent Elispe® placements, at 550 ml volume, in an outpatient fashion. All patients received a single pill 300 mg netupitant/0.5 mg palonosetron 6 h prior to placement. All patients received ondansetron 4 mg prescription to be taken as needed. A daily VAS score to report intensity of nausea, vomit, cramps, gastric pain, satiety for the first week post-placement was completed.
Results:
4/30 (13%) reported vomiting on days 1, 2, and 3; 9/30 (30%) reported nausea higher than score 4 on days 1, 2, and 3; 8/30 (26.6%) reported gastric pain higher than score 4 on days 1, 2, and 3.
Conclusion:
In our experience, the use of a single-pill netupitant/palonosetron resulted to be very easy to administer and effective in reducing vomit, nausea, and gastric pain in 87%, 70%, and 73.4% patients respectively, ameliorating the post Elipse™ placements symptoms safely.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP135729623	Palonosetron hydrochloride		135729-62-3	Price

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