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In-situ Synthesis of Acylated Sodium Alginate-G-(Tetrahydrofuran

In-situ Synthesis of Acylated Sodium Alginate-G-(Tetrahydrofuran

Yu-Zhuang Gao, Tian-Xiao Chang, Yi-Xian Wu

Carbohydr Polym. 2019 Sep 1;219:201-209.

PMID: 31151517

Abstract:

Sodium alginate (SA) is a marine-derived biocompatible polysaccharide with huge reserves and polyisobutylene (PIB) is a saturated elastomer with gas barrier property, bio-inertness, and biocompatibility. Herein, we developed the biomass-based ASA-g-(THF5-b-PIB) graft copolymer/Ag (3-11 nm, 0.7-3.8%) nanocomposites formed in-situ via combination of transition of terminal groups in PIB chains with grafting-onto method. The above graft copolymers exhibit microphase separation by self-assembly for the difference in chemical structure from backbone and branches and annealing process as well. The crystallization morphology from backbone depends on the Mn,PIB and GN, changing from thin strip to rod-like crystal. The pH sensitivity happens in drug release behavior of ASA-g-(THF5-b-PIB) micelles, which reach 100% of drug-release within 40 h at pH = 7.4. The ASA-g-(THF5-b-PIB)/Ag composites behave good antibacterial properties to both E. coli and S. aureus and anti-protein adsorption performance. This novel graft copolymer with comprehensive properties and would have a prospect in biomedical field.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9003274	Polyisobutylene		9003-27-4	Price

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