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In-vitro Activities of Imipenem-Colistin, Imipenem-Tigecycline, and Tigecycline-Colistin Combinations Against Carbapenem-Resistant Enterobacteriaceae

In-vitro Activities of Imipenem-Colistin, Imipenem-Tigecycline, and Tigecycline-Colistin Combinations Against Carbapenem-Resistant Enterobacteriaceae

Devrim Dundar, Zehra Duymaz, Serpil Genc, Doganhan Kadir Er, Arzu İrvem, Neslisah Kandemir

J Chemother. Oct-Dec 2018;30(6-8):342-347.

PMID: 30663555

Abstract:

The aim of the study is to determine in-vitro effects of imipenem-tigecycline, imipenem-colistin and tigecycline-colistin against carbapenem-resistant Enterobacteriaceae (CRE) isolates. A total of 25 CRE isolates were included to the study. The minimum inhibition concentrations of imipenem, colistin-sulphate and tigecycline were determined with broth dilution method. Synergistic effects of imipenem-tigecycline, imipenem-colistin and tigecycline-colistin were investigated by microdilution checkerboard technique. All of the isolates were resistant to imipenem, whereas 25% of the isolates were resistant to colistin and tigecycline. Imipenem-colistin, imipenem-tigecycline and tigecycline-colistin combinations were synergistic against 40% (10/25), 24% (6/25), and 36% (9/25) of the isolates, respectively. Antagonism was observed in 8% (2/25) of the isolates in tigecycline-colistin combination. Tigecycline-colistin was the most effective (70% synergy) combination in Klebsiella spp. strains; whereas imipenem-colistin was the most effective (75% synergy) combination in Escherichia coli strains. Synergistic effect was variable and strain-depended against CRE isolates that have been tested.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP74431235-A	Imipenem		74431-23-5	Price

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