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In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli

James A Karlowsky, Heather J Adam, Melanie R Baxter, Andrew J Denisuik, Philippe R S Lagacé-Wiens, Andrew J Walkty, Sailaja Puttagunta, Michael W Dunne, George G Zhanel

Antimicrob Agents Chemother. 2018 Dec 21;63(1):e01832-18.

PMID: 30397056

Abstract:

The in vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of Escherichia coli from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC50) and 90% (MIC90) of isolates tested; sulopenem MICs ranged from 0.015 to 0.25 µg/ml. The in vitro activity of sulopenem was unaffected by nonsusceptibility to trimethoprim-sulfamethoxazole and/or ciprofloxacin, multidrug-resistant phenotypes, extended-spectrum β-lactamases, or AmpC β-lactamases.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP120788070 Sulopenem Sulopenem 120788-07-0 Price
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