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In Vitro Antitumor Activity of Polymyxin Acylase From Pseudomonas Sp. M-6-3

In Vitro Antitumor Activity of Polymyxin Acylase From Pseudomonas Sp. M-6-3

N Yasuda, H Matsunaga, Y Kimura, M Tanaka, T Sasaki

Biol Pharm Bull. 1995 Apr;18(4):615-7.

PMID: 7655438

Abstract:

Polymyxin acylase from Pseudomonas sp. M-6-3 can deacylate not only polymyxin group antibiotics, but also the long-chain fatty acyl group of proteins and peptides. We found the in vitro antitumor activity of polymyxin acylase against murine and human tumor cells, especially KB cells. The mechanism of the antitumor activity remains equivocal, but we speculate that it may result from the affinity of polymyxin acylase for long-chain fatty acyl proteins in human carcinoma cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP111174437	Polymyxin Acylase from Pseudomonas sp.		111174-43-7	Price

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