Home
Resources
Publications
In Vitro Bactericidal Activity of Amoxicillin Combined With Different Cephalosporins Against Endocarditis-Associated Enterococcus Faecalis Clinical Isolates

In Vitro Bactericidal Activity of Amoxicillin Combined With Different Cephalosporins Against Endocarditis-Associated Enterococcus Faecalis Clinical Isolates

Nathan Peiffer-Smadja, Elena Guillotel, David Luque-Paz, Naouale Maataoui, F-Xavier Lescure, Vincent Cattoir

J Antimicrob Chemother. 2019 Dec 1;74(12):3511-3514.

PMID: 31495901

Abstract:

Background:
The combination of amoxicillin with cefazolin could be an interesting regimen for the empirical therapy of severe infective endocarditis, but its activity against enterococci is unknown.
Objectives:
To evaluate in vitro the bactericidal activity of the combination of amoxicillin with different cephalosporins including cefazolin.
Methods:
Combinations of amoxicillin (at MIC×¼) with cefazolin, cefotaxime, ceftriaxone, cefepime, ceftaroline or ceftobiprole (at the mean free plasma concentration) were studied using time-kill experiments for 10 endocarditis-associated Enterococcus faecalis strains and 2 reference strains.
Results:
The combinations amoxicillin/cefazolin, amoxicillin/cefotaxime, amoxicillin/ceftriaxone and amoxicillin/cefepime were synergistic at 12 and 24 h against 12/12 strains and amoxicillin/ceftobiprole and amoxicillin/ceftaroline against 10/12 strains. The combination amoxicillin/cefepime was bactericidal at 24 h against 9/12 strains, the combination amoxicillin/cefazolin against 8/12 strains, the combinations amoxicillin/ceftaroline, amoxicillin/cefotaxime and amoxicillin/ceftobiprole against 7/12 strains and the combination amoxicillin/ceftriaxone against 6/12 strains.
Conclusions:
The combination amoxicillin/cefazolin is as synergistic and bactericidal in vitro as amoxicillin/cefotaxime or amoxicillin/ceftriaxone against E. faecalis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61336707-A	Amoxicillin		61336-70-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: