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In Vitro Evaluation of E-4695, a New Fluoro-Naphthyridine

In Vitro Evaluation of E-4695, a New Fluoro-Naphthyridine

R N Jones

Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):188-94.

PMID: 1327787

Abstract:

Compound E-4695, a C-7 azetidinyl fluoro-naphthyridine, was compared to six structurally related quinolones and was generally two- to four-fold more active than ciprofloxacin. E-4695 was particularly active against Staphylococcus aureus (MIC90 0.06 mg/l), Staphylococcus haemolyticus (MIC90 0.5 mg/l), Klebsiella spp. (MIC90 less than or equal to 0.015 mg/l), Serratia marcescens (MIC90 0.06 mg/l), Acinetobacter spp. (MIC90 less than or equal to 0.015 mg/l), Pseudomonas aeruginosa (MIC90 0.5 mg/l), Xanthomonas maltophilia (MIC90 0.5 mg/l), and Neisseria gonorrhoeae (MIC90 less than or equal to 0.001 mg/l). This new quinolone-like drug requires further investigations to confirm these promising in vitro findings.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP75001784	Norfloxacin Related Compound E		75001-78-4	Price

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