Home
Resources
Publications
In Vitro Evaluation of Thio-Poly Acrylic Acid for Intraoral Delivery

In Vitro Evaluation of Thio-Poly Acrylic Acid for Intraoral Delivery

Flavia Laffleur, Nina Leder, Jan Barthelmes

Drug Deliv. 2016 Jul;23(6):2065-73.

PMID: 26666520

Abstract:

Context:
Intraoral drug delivery as mucosal delivery pathway provides a huge platform in the pharmaceutical field.
Objective:
Combining mucoadhesiveness and controlled release of thio-poly acrylic acid as advanced excipient for buccal drug delivery.
Materials and methods:
Mediated by carbodiimide, cysteine was covalently attached to poly acrylic acid. This thiomer was assessed with regard to cytotoxicity, stability, mucoadhesion, and rheology as well as release behavior of Lidocaine.
Results:
Stability assays of thio-poly acrylic acid were complying with United States Pharmacopeia requirements. Mucoadhesion assay such as tensile (total work of adhesion), bioadhesion, rotating cylinder revealed as this thiomer was superior in comparison to non-thiolated poly acrylic acid with 7.61-fold, 2.8-fold, 5.61-fold improvement, respectively without any toxic effect. The cell viability exhibited over 90% after incubation time of 3 h and 24 h respectively. Lidocaine release showed 1.98-fold more controlled release over 3 h in comparison to unmodified poly acrylic acid.
Conclusion:
Taken the findings in consideration, thio-poly acrylic acid provides excellent stability, controlled release, and superior mucoadhesive features. The prolonged residence time of thio-poly acrylic acid represents a pillar in the buccal drug delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9003014	Poly(acrylic acid)		9003-01-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: