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In vitro/in Vivo and Analytical Evaluation of Sunless Tanning Formulations Containing Different Rheology Modifiers

In vitro/in Vivo and Analytical Evaluation of Sunless Tanning Formulations Containing Different Rheology Modifiers

Olga V Dueva-Koganov, Yamini Mandalia, Juan Brito, Colleen Rocafort, Steven Orofino, Gustavo Vazquez

J Cosmet Sci. Mar-Apr 2010;61(2):73-83.

PMID: 20447361

Abstract:

In vitro data suggest that different in vivo performances are expected for two dihydroxyacetone (DHA)-containing formulations with similar concentrations of DHA and excipients but different commercially available rheology modifiers: one with a cationic polymer-based rheology modifier (blend) [dimethylacrylamide/ethyltrimonium chloride methacrylate copolymer (and) propylene glycol dicaprylate/dicaprate (and) PPG-1 trideceth-6 (and) C10-11 isoparaffin]; and the other with a polyacrylamide-based rheology modifier (blend) [polyacrylamide (and) C13-14 isoparaffin (and) laureth-7]. Both rheology modifiers (blends) contained comparable levels of polymers and were used at 3% w/w (as supplied). Differences in color development were illustrated in vitro with respect to the yellow/red and lightness/chroma parameters, which were confirmed in the followup in vivo studies. The test article with the cationic polymer-based rheology modifier produced a more natural sunless tan, comparable to a desirable sun-induced tan, for all panelists, one that was more uniform and lasted longer compared with the sunless tan generated by the test article with the polyacrylamide-based rheology modifier. A method for HPLC analysis of DHA in sunless tanning formulations was established and utilized to confirm concentrations of DHA in test articles.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68583517	Propylene Glycol Dicaprylate/Dicaprate		68583-51-7	Price

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