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In Vivo Characterization of Monolithic Matrix Type Transdermal Drug Delivery Systems of Pinacidil Monohydrate: A Technical Note

Mohd Aqil, Asgar Ali, Yasmin Sultana, Kiran Dubey, Abul K Najmi, Kollapa K Pillai

AAPS PharmSciTech. 2006 Jan 13;7(1):E6.

PMID: 16584165

Abstract:

The present work aimed to characterize transdermal drug delivery systems of pinacidil monohydrate in vivo by monitoring the effect of the TDDS on blood pressure of methyl prednisolone acetate induced hypertensive rats. The blood pressure of rats was measured using a noninvasive rat BP instrument based on cuff tail technique. A significant fall in rat BP (P<.01) was observed in treatment of hypertensive rats with all the formulations, which was maintained for 48 hours. Interformulation comparison revealed that formulation B-4 was the most effective with 37.96% reduction in BP (160.33±4.96 vs 99.44±4.46 mmHg). It was concluded that a single patch application of pinacidil TDDS (B-4) can effectively control hypertension in rats for 2 days. The system holds promise for clinical studies.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP85371648 Pinacidil monohydrate Pinacidil monohydrate 85371-64-8 Price
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