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In Vivo Metabolism of 2,2',4,4'-tetrabromodiphenyl Ether (BDE-47) in Young Whole Pumpkin Plant

In Vivo Metabolism of 2,2',4,4'-tetrabromodiphenyl Ether (BDE-47) in Young Whole Pumpkin Plant

Jianteng Sun, Jiyan Liu, Miao Yu, Chang Wang, Yuzhen Sun, Aiqian Zhang, Thanh Wang, Zhen Lei, Guibin Jiang

Environ Sci Technol. 2013 Apr 16;47(8):3701-7.

PMID: 23510101

Abstract:

Polybrominated diphenyl ethers (PBDEs) are widely distributed persistent organic pollutants. In vitro and in vivo research using various animal models have shown that PBDEs might be transformed to hydroxylated PBDEs, but there are few studies on in vivo metabolism of PBDEs by intact whole plants. In this research, pumpkin plants (Cucurbita maxima × C. moschata) were hydroponically exposed to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47). A debromination product (BDE-28) and four hydroxylated metabolites (5-OH-BDE-47, 6-OH-BDE-47, 4'-OH-BDE-49, and 4-OH-BDE-42) were detected in different parts of the whole plant. In addition, 4-methoxylated-2,2',3,4'-tetraBDE (4-MeO-BDE-42) was observed as a methoxylation product. Root exudates in solution were found to play an important role in metabolizing BDE-47 to a specific OH-PBDE: 4'-OH-BDE-49. BDE-28 was found to translocate more easily and accumulate in shoots than BDE-47 due to the lower hydrophobicity and molecular weight. The concentration ratio between metabolites and parent compound BDE-47 was lower for OH-PBDEs than that for both BDE-28 and 4-MeO-BDE-42. The metabolism pathway of BDE-47 in young whole plants was proposed in this study.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP243982823	BDE No 49 solution		243982-82-3	Price

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