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Inactivation of Aztreonam by Faecal Supernatants of Healthy Volunteers as Determined by HPLC

G W Welling, G Groen

J Antimicrob Chemother. 1989 Nov;24(5):805-9.

PMID: 2600000

Abstract:

The enzymatic inactivation of aztreonam to its biologically inactive open ring form, by faecal enzyme preparations from 12 volunteers, was investigated. The percentage inactivation was determined by a high-performance liquid chromatography assay at months 0, 6 and 24. Faecal enzyme preparations from five volunteers could inactivate aztreonam by more than 50% within 20 h at one or more of these sampling times. Monitoring of aztreonam inactivation over a shorter period of time (14 days) in three of the volunteers showed that aztreonam inactivation cannot be predicted.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP87500741 Open Ring Aztreonam Open Ring Aztreonam 87500-74-1 Price
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