Home
Resources
Publications
Inclusion of Tetracycline Hydrochloride Within Supramolecular Gels and Its Controlled Release to Bovine Serum Albumin

Inclusion of Tetracycline Hydrochloride Within Supramolecular Gels and Its Controlled Release to Bovine Serum Albumin

Liqin Chen, Junchen Wu, Lihui Yuwen, Tianmin Shu, Miao Xu, Mingming Zhang, Tao Yi

Langmuir. 2009 Aug 4;25(15):8434-8.

PMID: 19326874

Abstract:

Three amphiphilic 3,4,5-trihydroxybenzoic derivatives with alkyl chains of different lengths were designed and synthesized. A small amount of these compounds can trap a large quantity of the water-soluble drug tetracycline hydrochloride (TH) within a stable gel in aqueous ethanol. Release experiments were carried out with solutions of bovine serum albumin (BSA) and various concentrations of L-isoleucine, L-phenylalanine, and L-tryptophan. The results indicate that the release rate of TH for a BSA solution (10 mg/mL) was faster than that with the other solutions because of the strong interaction between TH and BSA. Furthermore, to gain an insight into the release dynamics, we studied the release ratios as a function of the square root of time (t1/2). During the initial 1.75 h, diffusion is the dominant release process in water, whereas intermolecular interaction controls TH release in the BSA solution.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17585692	L-Phenylalanine hydrochloride solution		17585-69-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: