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Increase in Water Permeability of Negatively Charged Liposomal Membrane by Local Anesthetics

Increase in Water Permeability of Negatively Charged Liposomal Membrane by Local Anesthetics

T Shimooka, S Seto, H Terada

Chem Pharm Bull (Tokyo). 1992 Jul;40(7):1880-2.

PMID: 1394708

Abstract:

Effect of the local anesthetics dibucaine, tetracaine, lidocaine and procaine on the water permeability of phospholipid membrane was examined using liposomes composed of bovine heart cardiolipin and egg yolk phosphatidylcholine in a molar ratio of 2/98 by monitoring the osmotic shrinkage of liposomes in hypertonic glucose solution at pH 7.3 and 30 degrees C. These local anesthetics greatly accelerated the water permeability by destabilizing the membrane structure. The effect was found to be governed by the hydrophobicity of the anesthetics. There was also a significant correlation between the membrane destabilizing actions and the anesthetic activities.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4247129	Cardiolipin solution from bovine heart			Price

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