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Increased Blood 8-hydroxy-2-deoxyguanosine Levels in Methamphetamine Users During Early Abstinence

Increased Blood 8-hydroxy-2-deoxyguanosine Levels in Methamphetamine Users During Early Abstinence

Ming-Chyi Huang, Ying-Ching Lai, Shih-Ku Lin, Chun-Hsin Chen

Am J Drug Alcohol Abuse. 2018;44(3):395-402.

PMID: 28726514

Abstract:

Background:
Reactive oxygen species (ROS) are thought to play a role in the adverse physical and mental consequences of methamphetamine usage. The oxidative DNA adduct 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a well-known biomarker of ROS-induced DNA damage. Currently, there is insufficient clinical information about methamphetamine-induced oxidative DNA damage.
Objectives:
This study examined differences in blood levels of 8-OHdG between methamphetamine users and non-users as well as alterations in 8-OHdG levels after 2 weeks of methamphetamine abstinence.
Methods:
We recruited 182 methamphetamine users (78.6% of male) and 71 healthy controls (95.8% of male). Baseline serum 8-OHdG levels were measured in both groups using a competitive enzyme-linked immunosorbent assay. In methamphetamine users, 8-OHdG levels were measured again 2 weeks after baseline measurement.
Results:
The results showed that methamphetamine users had significantly higher 8-OHdG levels (0.34 ± 0.13 ng/mL) than healthy controls (0.30 ± 0.08 ng/mL) (p < 0.001). The 8-OHdG levels did not alter after 2 weeks of methamphetamine abstinence (0.32 ± 0.12 ng/mL, p = 0.051 compared to baseline measurement; p = 0.12 compared to healthy controls). No significant correlations were observed between baseline 8-OHdG levels in methamphetamine users and post-abstinence interval, age of the first methamphetamine use, duration of methamphetamine use, or history of frequent methamphetamine use.
Conclusion:
Our findings suggest that methamphetamine users had an enhanced level of oxidative damage, which did not normalize during early abstinence. Future studies are required to determine the effects of long-term methamphetamine abstinence and potential confounders on 8-OHdG levels in methamphetamine users.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP88847896	8-Hydroxy-2′-deoxyguanosine		88847-89-6	Price

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