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[Increased Expression of IL-16 in Mouse Skin Allograft]

[Increased Expression of IL-16 in Mouse Skin Allograft]

Chunxia Li, Hui Zhang, Jin Qu, Jun Dai, Qun Ma, Zhihua Li, Bo Wang, Chuanping Si

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Sep;31(9):1220-3.

PMID: 26359104

Abstract:

Objective:
To detect the expression of interleukin 16 (IL-16) in skin allografts of recipient mice and the serum level of IL-16.
Methods:
Two different mouse models of skin allografts were used: the isotransplant group (C57BL/6--C57BL/6, n=45) and the allotransplantation group (BALB/c--C57BL/6, n=45). The level of IL-16 in sera and skin graft homogenates was tested by ELISA at 1, 3, 5 and 7 days after transplantation and the expression of IL-16 mRNA in skin allografts was measured by reverse transcription PCR at the same time points.
Results:
At 3, 5 and 7 days after skin transplantation, the levels of IL-16 protein and mRNA in the skin allografts and serum level of IL-16 in the allotransplantation group were significantly higher than those in the isotransplant group.
Conclusion:
The expression of IL-16 is increased in the mouse skin allografts.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413356	IL-16 from mouse			Price

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