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Indium-promoted Chemo- And Diastereoselective Allylation of α,β-epoxy Ketones With Potassium Allyltrifluoroborate

Farhad Nowrouzi, John Janetzko, Robert A Batey

Org Lett. 2010 Dec 3;12(23):5490-3.

PMID: 21070014

Abstract:

A practical method for the chemo- and diastereoselective allylation of α,β-epoxy ketones has been developed by using the convenient air and moisture stable reagent potassium allyltrifluoroborate. Indium metal was found to promote addition in stoichiometric or catalytic amounts, to afford α,β-epoxyhomoallylic tertiary alcohols in high yields and diastereoselectivities, without competing ring-scission of the epoxide.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP233664534 Potassium allyltrifluoroborate Potassium allyltrifluoroborate 233664-53-4 Price
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