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Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury

Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury

Kosuke Dodo, Tadashi Shimizu, Jun Sasamori, Kazuyuki Aihara, Naoki Terayama, Shuhei Nakao, Katsuya Iuchi, Masahiro Takahashi, Mikiko Sodeoka

ACS Med Chem Lett. 2018 Jan 29;9(3):182-187.

PMID: 29541357

Abstract:

We previously developed IM-54 as a novel type of inhibitor of hydrogen-peroxide-induced necrotic cell death. Here, we examined its cell death inhibition profile. IM-54 was found to selectively inhibit oxidative stress-induced necrosis, but it did not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis. IM-17, an IM derivative having improved water-solubility and metabolic stability, was developed and confirmed to retain necrosis-inhibitory activity. IM-17 showed cardioprotective effects in an isolated rat heart model and an in vivo arrhythmia model, suggesting that IM derivatives may have therapeutic potential.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP861891501	IM-54		861891-50-1	Price

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