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Induction of Long-Lasting Depression by (+)-alpha-methyl-4-carboxyphenylglycine and Other Group II mGlu Receptor Ligands in the Dentate Gyrus of the Hippocampus in Vitro

Induction of Long-Lasting Depression by (+)-alpha-methyl-4-carboxyphenylglycine and Other Group II mGlu Receptor Ligands in the Dentate Gyrus of the Hippocampus in Vitro

L Huang, M J Rowan, R Anwyl

Eur J Pharmacol. 1999 Feb 5;366(2-3):151-8.

PMID: 10082195

Abstract:

Application of several well characterized group II mGlu receptor ligands was found to induce a long-lasting depression of synaptic transmission in the medial perforant path of the dentate gyrus. These ligands were N-acetylaspartylglutamate (NAAG), which is a dipeptide located in the brain and possibly functioning as a neurotransmitter, two agents widely used previously as mGluR antagonists, (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), and (S)-alpha-ethylglutamate (EGLU), and the well characterized group II mGluR agonist (2S,1R,2R,3R)-2-(2S,1'R,2'R,3'R)-2(2'3'-dicarboxycyclopropyl)glyci ne (DCG-IV). It is postulated that all these ligands induced the long-lasting depression by an agonist/partial agonist action at group II mGlu receptor. The long-lasting depression induced by the ligands showed mutual occlusion with low frequency stimulation-induced long-term depression, demonstrating common induction or maintenance mechanisms. The induction of the long-lasting depression by the mGlu receptor ligands are suggested to occur postsynaptically as the induction was not associated with a change in paired pulse depression of excitatory postsynaptic potentials (EPSPs).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP150145894	(+)-α-Methyl-4-carboxyphenylglycine		150145-89-4	Price

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