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Induction of Neuronal Differentiation in Neurosphere Stem Cells by Ellagic Acid Derivatives

Induction of Neuronal Differentiation in Neurosphere Stem Cells by Ellagic Acid Derivatives

Turibio Kuiate Tabopda, Joseph Ngoupayo, Jia Wei Liu, Anne-Claire Mitaine-Offer, Bonaventure Tchaleu Ngadjui, Marie-Aleth Lacaille-Dubois, Bang Luu

Nat Prod Commun. 2009 Apr;4(4):517-20.

PMID: 19475997

Abstract:

A bioassay-guided fractionation of methanol extracts of stem barks, combined with screening based on Epidermal Growth Factor (EGF)-responsive neural stem cells (erNSCs) differentiation assay, has been used. This study resulted in the isolation of 3,3'-di-O-methylellagic acid 1, 3,3'-di-O-methyl ellagic acid-4-O-beta-D-xylopyranoside 2, ellagic acid 3, and arjunolic acid 4. Among them, compounds 1 and 2 exhibit potent induction of neuronal differentiation in neurosphere stem cells with no cytotoxic effect. These results indicate that compounds 1 and 2 may be useful as pharmacological agents for the treatment of neurodegenerative diseases. These compounds may account, for the use of T. superba in folk medicine for nervous system and mental disorders.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP62218239	3,3′-Di-O-methyl ellagic acid 4′-O-β-D-xylopyranoside		62218-23-9	Price

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