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Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed

Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed

Megan C Niederwerder, Ana M M Stoian, Raymond R R Rowland, Steve S Dritz, Vlad Petrovan, Laura A Constance, Jordan T Gebhardt, Matthew Olcha, Cassandra K Jones, Jason C Woodworth, Ying Fang, Jia Liang, etc.

Emerg Infect Dis. 2019 May;25(5):891-897.

PMID: 30761988

Abstract:

African swine fever virus (ASFV) is a contagious, rapidly spreading, transboundary animal disease and a major threat to pork production globally. Although plant-based feed has been identified as a potential route for virus introduction onto swine farms, little is known about the risks for ASFV transmission in feed. We aimed to determine the minimum and median infectious doses of the Georgia 2007 strain of ASFV through oral exposure during natural drinking and feeding behaviors. The minimum infectious dose of ASFV in liquid was 100 50% tissue culture infectious dose (TCID50), compared with 104 TCID50 in feed. The median infectious dose was 101.0 TCID50 for liquid and 106.8 TCID50 for feed. Our findings demonstrate that ASFV Georgia 2007 can easily be transmitted orally, although higher doses are required for infection in plant-based feed. These data provide important information that can be incorporated into risk models for ASFV transmission.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP30675139	TCID		30675-13-9	Price

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