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Influence of Carboxymethylcellulose Sodium and Lutrol on the Swelling Index and Disintegration Time of Biomucoadhesive Tablets with Miconazole Nitrate

Influence of Carboxymethylcellulose Sodium and Lutrol on the Swelling Index and Disintegration Time of Biomucoadhesive Tablets with Miconazole Nitrate

Magdalena Birsan, Monica Mihaela Scutariu, Ileana Cojocaru

Rev Med Chir Soc Med Nat Iasi. Apr-Jun 2016;120(2):445-51.

PMID: 27483733

Abstract:

PURPOSE. To develop original pharmaceutical formulation with miconazole nitrate, biomucoadhesive tablets, used in antifungal medication.
Material and methods:
The oral biomucoadhesive tablets with miconazole nitrate were developed by direct compression of the excipient mixture: carboxymethylcellulose sodium and lutrol 6000, excipients used for bioadhesivity, mannitol as a sugar substitute and aerosil as a lubricant. The main goal of the study is to determine the disintegration time and the swelling index of biomucoadhesive tablets with miconazole nitrate in order to estimate the time of contact with mucosa, respectively the prolongation of drug substance release.
Results:
The swelling index was calculated depending on time in all the 5 formulations that included the carboxymethylcellulose sodium and Lutrol 6000 as matrix-forming, and the studied were time and association ratio between polymers.
Conclusions:
Analysing the results, we noticed that out of the four excipients we used, carboxymethylcellulose sodium had the higher influence on the swelling index and disintegration time.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9004324	Carboxymethylcellulose sodium		9004-32-4	Price

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