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[Influence of Frequent Instillations of Anti-Infective Solutions on Eye Tissues (An Experimental Study)]

[Influence of Frequent Instillations of Anti-Infective Solutions on Eye Tissues (An Experimental Study)]

E A Kasparova, A A Fedorov, O I Sobkova

Vestn Oftalmol. 2019;135(5. Vyp. 2):160-170.

PMID: 31691655

Abstract:

Purpose:
To investigate the toxic effects of frequent instillations of anti-infective solutions (antibiotic eye drops - 0.3 and 1.4% tobramycin, 0.5% levofloxacin and 0.5% moxifloxacin; antiseptic eye drops - 0.05% pyloxidine and 0.025% chlorhexidine; antifungal drug - 2 mg/ml fluconazole solution) on ocular tissues.
Material and methods:
The study was conducted on 21 Wistar rats (42 eyes) using method of semi-fine sections.
Results:
The majority of antibiotics and antifungal agents do not cause toxic reactions in rats` eyes when instilled with frequent regimen with the exception of 'fortified' 1.4% tobramycin and pyloxidine solutions, which caused a decrease in corneal endothelial cells density and formation of fibrovascular tissue in the anterior chamber.
Conclusion:
Frequent instillations of antimicrobial drug solutions is a safe method for the treatment of purulent corneal ulcers and purulent keratitis. The exceptions were solutions of 'fortified' 1.4% tobramycin and piloxidine (vitabact).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP86386734-A	Fluconazole solution		86386-73-4	Price

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