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Influence of Organotins on Rat Platelet Aggregation Mechanisms

Influence of Organotins on Rat Platelet Aggregation Mechanisms

C O Knowles, T L Johnson

Environ Res. 1986 Feb;39(1):172-9.

PMID: 3943507

Abstract:

The effects of ten organotins on rat platelet aggregation mechanisms were examined. Bis(tri-n-butyltin)oxide was the most potent inhibitor of both ADP- and collagen-induced aggregation, and it was the only organotin that directly induced aggregation. It also increased the latent period for induction of aggregation by collagen. Triphenyltin hydroxide was a weak inhibitor of both ADP- and collagen-induced aggregation. However, in contrast to bis(tri-n-butyltin)oxide, it decreased the latent period for collagen-induced aggregation. A similar effect also was observed with diphenyltin dichloride, phenyltin trichloride, and cyhexatin. Tri-n-butyltin chloride and tetra-n-butyltin demonstrated specificity in their action since aggregation induced by ADP but not collagen was inhibited. Tri-n-propyltin chloride, trimethyltin chloride, and fenbutatin oxide were without discernible effect on rat platelet aggregation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1124192	Phenyltin trichloride		1124-19-2	Price

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