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Influence of Preoperative Serum Creatinine Level and Intraoperative Volume of Contrast Medium on the Risk of Acute Kidney Injury After Transfemoral Transcatheter Aortic Valve Implantation: A Retrospective Observational Study

Influence of Preoperative Serum Creatinine Level and Intraoperative Volume of Contrast Medium on the Risk of Acute Kidney Injury After Transfemoral Transcatheter Aortic Valve Implantation: A Retrospective Observational Study

Daisuke Miura, Yasutaka Yamada, Shinichiro Kusaba, Eijiro Nogami, Junji Yunoki, Yoshiko Sakamoto, Yutaka Hikichi, Koichi Node, Yoshiro Sakaguchi

BMC Res Notes. 2019 Aug 5;12(1):484.

PMID: 31383003

Abstract:

Objective:
This study aimed to determine if contrast medium volume (CMV) is a risk factor for acute kidney injury (AKI) during transcatheter aortic valve implantation (TAVI) via a transfemoral approach performed without major complications. All TAVI procedures performed at our institution between March 2014 and March 2018 were retrospectively reviewed. AKI was diagnosed using the Acute Kidney Injury Network classification based on the Valve Academic Research Consortium-2 definition. Procedures performed via a transapical approach and those in which circulatory dynamics failed intraoperatively were excluded.
Results:
Eighty-one (96.4%) of 100 patients scheduled for TAVI were enrolled; seven (8.6%) developed AKI and 74 (91.4%) did not. The serum creatinine (SCr) level was significantly higher (p < 0.05) and the estimated glomerular filtration rate was significantly lower in the AKI group (p < 0.05). The CMV was significantly higher in the AKI group (103 ml vs 84 ml, p < 0.05), as was the CMV × SCr/BW value (3.34 vs 1.49, p < 0.01). The area under the curve for CMV × SCr/BW was 0.9228 and the cut-off value was 2.99. The CMV, SCr, and estimated glomerular filtration rate affect the likelihood of AKI after transfemoral TAVI and a CMV × SCr/BW value > 2.99 accurately predicts AKI.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS2121436	Human serum (medium creatinine)			Price

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