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Influence of Sunscreening Agents on Color Stability of Tablets Coated With Certified Dyes III: FD&C Yellow No. 6

Influence of Sunscreening Agents on Color Stability of Tablets Coated With Certified Dyes III: FD&C Yellow No. 6

B R Hajratwala, A J Hennig

J Pharm Sci. 1977 Jan;66(1):107-9.

PMID: 833722

Abstract:

The influence of a protective coating of six sunscreening agents (glyceryl p-aminobenzoate, benzocaine, cinoxate, homosalate, n-octyl salicylate, and amyl salicylate) upon the photostability of FD&C Yellow No. 6 used to color coat tablets was studied. The alcohol film, modified sugar-, and film-coating methods were used to apply the sunscreening agents. Tablets were exposed to 1000 foot-candles of light for various times, after which reflectance measurements and visual observations were recorded. FD&C Yellow No. 6 did not follow the Kubelka-Munk equation. The order of relative stability was FD&C Yellow No. 6 greater than erythrosine sodium (FD&C Red No. 3) greater than FD&C Blue No. 1. The greatest protection against fading was afforded by benzocaine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP104289	Cinoxate		104-28-9	Price
AP2050080	Amyl salicylate		2050-08-0	Price

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