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[Influencing of Acetylation and Corticosterone Biosynthesis Through Long-Term Pantothenic Acid Deficiency in Rats]

[Influencing of Acetylation and Corticosterone Biosynthesis Through Long-Term Pantothenic Acid Deficiency in Rats]

K Pietrzik, Ch Hesse, D Hötzel

Int J Vitam Nutr Res. 1975;45(3):251-61.

PMID: 1184292

Abstract:

The effect of different dietary intake of pantothenic acid (150;100;25 and 0% of the requirement) on the metabolism of rats was studied during 15 months. The ability of the adrenals for synthesis of corticosterone and the rate of acetylation of a sulfonamid (Sulfisomidin) were taken as parameters. The above mentioned parameters were influenced significantly already after two weeks and a pantothenic acid free diet containing the antagonist omega-methyl-pantothenic acid. With a 25% supply of pantothenic acid and without omega-methyl-pantothenic acid it lasted half a year until significant alterations of acetylation could be demonstrated. The synthetic ability of the adrenals for corticosteroids was significantly increased after a year in the 25% group. After the end of the study, this hyperfunctional state was followed by hypofunction, resulting in a significantly reduced ability of synthesis of the glands. Studies of this type were conducted to obrain basic informations for later experiments in human beings.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP515640	Sulfisomidin		515-64-0	Price

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