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Inhibition Effects of Selected thiophene-2-sulfonamides on Lactoperoxidase

Inhibition Effects of Selected thiophene-2-sulfonamides on Lactoperoxidase

Zeynep Köksal

Drug Chem Toxicol. 2019 Apr 22;1-6.

PMID: 31010344

Abstract:

Lactoperoxidase (LPO, E.C.1.11.1.7) is a natural antibacterial agent which is secreted from salivary, mammary, and other mucosal glands. It is one of the crucial enzymes in biological systems, so protection of LPO activity is extremely important for the immune system. Within the scope of this study; in vitro effects of some thiophene-2-sulfonamide derivatives (1a-7a) on bovine milk LPO enzymatic activity were investigated. LPO was purified from the Sepharose-4B-L-tyrosine-5-amino-2-methylbenzenesulfonamide column prepared using affinity chromatography technique with a yield of 169.66 EU/mg specific activity in 452.44 times. As a result, 5-(2-thienylthio) thiophene-2-sulfonamide demonstrated the strongest inhibition impact among these compounds. This molecule has shown a competitive inhibition and it was determined that the IC50 value was 3.4 nM and the Ki value was 2 ± 0.6 nM.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP420089516	Thiophene-2		420089-51-6	Price

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