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Inhibition of Degranulation of Human Polymorphonuclear Leukocytes by Complement Factor D

N Balke, U Holtkamp, W H Hörl, H Tschesche

FEBS Lett. 1995 Sep 11;371(3):300-2.

PMID: 7556615

Abstract:

A degranulation inhibiting protein could be isolated from human plasma ultrafiltrate by a three-step purification method including ion-exchange chromatography, gelfiltration and affinity-chromatography. The protein was identified as complement factor D by means of sequence analysis. Its degranulation inhibiting activity was determined with regard to its effect on the FNLPNTL-induced lactoferrin secretion of human polymorphonuclear leukocytes. Complement factor D caused a dose-dependent decrease of the FNLPNTL-stimulated lactoferrin degranulation down to 34% of stimulated controls.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP37213562 Complement factor D from human plasma Complement factor D from human plasma 37213-56-2 Price
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