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Inhibition of Gli/hedgehog Signaling in Prostate Cancer Cells by "Cancer Bush" Sutherlandia Frutescens Extract

Inhibition of Gli/hedgehog Signaling in Prostate Cancer Cells by "Cancer Bush" Sutherlandia Frutescens Extract

Hui Lin, Glenn A Jackson, Yuan Lu, Sara K Drenkhahn, Korey J Brownstein, Nicholas J Starkey, William R Lamberson, Kevin L Fritsche, Valeri V Mossine, Cynthia L Besch-Williford, William R Folk, Yong Zhang, etc.

Cell Biol Int. 2016 Feb;40(2):131-42.

PMID: 26377232

Abstract:

Sutherlandia frutescens is a medicinal plant, traditionally used to treat various types of human diseases, including cancer. Previous studies of several botanicals link suppression of prostate cancer growth with inhibition of the Gli/hedgehog (Gli/Hh) signaling pathway. Here we hypothesized the anti-cancer effect of S. frutescens was linked to its inhibition of the Gli/Hh signaling in prostate cancer. We found a dose- and time-dependent growth inhibition in human prostate cancer cells, PC3 and LNCaP, and mouse prostate cancer cell, TRAMP-C2, treated with S. frutescens methanol extract (SLE). We also observed a dose-dependent inhibition of the Gli-reporter activity in Shh Light II and TRAMP-C2QGli cells treated with SLE. In addition, SLE can inhibit Gli/Hh signaling by blocking Gli1 and Ptched1 gene expression in the presence of a Gli/Hh signaling agonist (SAG). A diet supplemented with S. frutescens suppressed the formation of poorly differentiated carcinoma in prostates of TRAMP mice. Finally, we found Sutherlandioside D was the most potent compound in the crude extract that could suppress Gli-reporter in Shh Light II cells. Together, this suggests that the S. frutescens extract may exert anti-cancer effect by targeting Gli/Hh signaling, and Sutherlandioside D is one of the active compounds.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1055329491	Sutherlandioside D		1055329-49-1	Price

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