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Inhibition of Glucose Oxidation by alpha-cyano-4-hydroxycinnamic Acid Stimulates Feeding in Rats

Inhibition of Glucose Oxidation by alpha-cyano-4-hydroxycinnamic Acid Stimulates Feeding in Rats

E Del Prete, T A Lutz, E Scharrer

Physiol Behav. 2004 Jan;80(4):489-98.

PMID: 14741234

Abstract:

Alpha-cyano-4-hydroxycinnamic acid (4-CIN, 100-200 mg/kg b.wt.), which impairs glucose oxidation by inhibiting pyruvate transport across the mitochondrial membrane, stimulated feeding in rats following intraperitoneal injection without affecting blood glucose level. Like 2-deoxy-D-glucose (2-DG), an inhibitor of glycolysis, 4-CIN probably acts mainly on the CNS through activation of alpha(2)-adrenergic receptors, because the feeding response to 4-CIN was eliminated by phentolamine or yohimbine. Unlike feeding elicited by 2-DG, 4-CIN-induced feeding was eliminated by total abdominal (but not hepatic branch) vagotomy. Since peripheral atropinization also blocked 4-CIN-induced feeding, activation of central parasympathetic neurons seems to be involved in 4-CIN-induced feeding. The feeding response to 4-CIN was diminished in rats fed a high-fat diet, probably because metabolic sensors sensing fatty acid oxidation counteract the feeding response to 4-CIN. The results suggest that inhibition of glucose oxidation by blocking pyruvate entry into mitochondria stimulates feeding in rats in particular when fed a high-carbohydrate diet.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP28166418	α-Cyano-4-hydroxycinnamic acid		28166-41-8	Price

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