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Inhibition of Hydrogen Peroxide-Induced Necrotic Cell Death With 3-amino-2-indolylmaleimide Derivatives

Inhibition of Hydrogen Peroxide-Induced Necrotic Cell Death With 3-amino-2-indolylmaleimide Derivatives

Kosuke Dodo, Miho Katoh, Tadashi Shimizu, Masahiro Takahashi, Mikiko Sodeoka

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3114-8.

PMID: 15878276

Abstract:

Novel analogs of indolylmaleimide derivatives (IM derivatives) were synthesized and tested for cell death-inhibitory activity. 2-(1H-Indol-3-yl)-3-pentylamino-maleimide IM-54 was the most effective cell death inhibitor among the compounds tested. IM-54 inhibited necrotic cell death induced by H2O2, but not apoptotic cell death induced by etoposide. These results indicated that this novel cell death inhibitor is distinct from the well-known caspase inhibitor, Z-VAD, which can block apoptotic cell death, but not necrotic cell death. IM-54 is expected to be a powerful bioprobe for clarifying the unique signaling pathway of necrotic cell death.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP861891501	IM-54		861891-50-1	Price

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