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Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages

Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages

Ewelina Szliszka, Dariusz Skaba, Zenon P Czuba, Wojciech Krol

Molecules. 2011 May 3;16(5):3701-12.

PMID: 21540797

Abstract:

Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP41060155	Neobavaisoflavone		41060-15-5	Price

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