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Inhibition of Microtubule Assembly in Vitro by TN-16, a Synthetic Antitumor Drug

Inhibition of Microtubule Assembly in Vitro by TN-16, a Synthetic Antitumor Drug

T Arai

FEBS Lett. 1983 May 8;155(2):273-6.

PMID: 6852237

Abstract:

An antitumor drug, 3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16) inhibited the assembly of porcine brain microtubules in vitro. The assembly induced by taxol was also suppressed by the drug. However, the latter required much higher concentration of TN-16 than the former. Binding studies by means of the fluorometric method and the spun-column procedure indicate that the inhibition was caused by the reversible binding of the drug to the colchicine-sensitive site of tubulin. The affinity of TN-16 to tubulin was almost equal to that of nocodazole.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33016125	TN-16		33016-12-5	Price

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