Home
Resources
Publications
Inhibitors of Diacylglycerol Metabolism Reduce Time to the Onset of Glutamate Release Potentation by mGlu7 Receptors

Inhibitors of Diacylglycerol Metabolism Reduce Time to the Onset of Glutamate Release Potentation by mGlu7 Receptors

José Javier Ferrero, Magdalena Torres, José Sánchez-Prieto

Neurosci Lett. 2011 Aug 15;500(2):144-7.

PMID: 21718754

Abstract:

At nerve terminals G protein coupled receptors modulate neurotransmitter release probability. We recently showed that prolonged activation of metabotropic glutamate receptor 7, mGlu7 receptor, potentiates glutamate release. This signalling involves phospholipase C activation via a pertussis toxin insensitive G protein, the hydrolysis of phosphatidylinositol (4,5)-bisphosphate, and the subsequent activation of the non-kinase diacylglycerol binding protein Munc13-1 which primes synaptic vesicle for exocytosis at the active zone. Here we found that inhibitors of diacylglycerol metabolism (diacylglycerol kinase inhibitor II and diacylglycerol lipase inhibitor RHC80267) remarkably reduce the time of mGlu7 receptor stimulation required for glutamate release potentiation in mice cerebrocortical nerve terminals. We conclude that changes in diacylglycerol levels at nerve terminals control the efficiency of the exocytotic release machinery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP120166690-A	Diacylglycerol Kinase Inhibitor II		120166-69-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: