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Inhibitory Activities Against Rice Pathogens of 8-hydroxy-2,4,6-octatriynamide From Agrocybe Sp

Inhibitory Activities Against Rice Pathogens of 8-hydroxy-2,4,6-octatriynamide From Agrocybe Sp

Yongbiao Zheng, Xiaoping Xu, Yabin Wu

World J Microbiol Biotechnol. 2016 Mar;32(3):35.

PMID: 26861586

Abstract:

8-Hydroxy-2,4,6-octatriynamide, a natural polyacetylene with inhibitory activities against rice pathogens, was isolated from the liquid fermentation broth of strain Agrocybe sp. YB2005 during screening for new natural chemical agents to control rice pathogens. 8-hydroxy-2,4,6-octatriynamide was purified by consecutive chromatography over a Cl8 reversed phase silica gel, sephadex LH-20 and silica gel. The chemical structure of 8-hydroxy-2,4,6-octatriynamide was elucidated through spectroscopic analyses, including 1D- and 2D-NMR, ESI mass spectrometry and X-ray single crystal diffraction. Bioassays showed that 8-hydroxy-2,4,6-octatriynamide could significantly inhibit growth of Xanthomonas oryzae with an MIC of 53.1 μM in a 96-well plate and the growth of Rhizoctonia solani at 1.02 mM in a 24-well plate. When rice leaves were inoculated with Magnaporthe grisea and cultured in artificial nutrition liquid containing 0.34 mM 8-hydroxy-2,4,6-octatriynamide, no rice blast was observed. The present study implied that 8-hydroxy-2,4,6-octatriynamide could be a candidate agent against rice pathogens.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6166865	2,4,6,8,10-Pentamethylcyclopentasiloxane		6166-86-5	Price

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