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Inhibitory Constituents of Sophora Tonkinensis on Nitric Oxide Production in RAW 264.7 Macrophages

Jin Woo Lee, Ji Hoon Lee, Chul Lee, Qinghao Jin, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Bioorg Med Chem Lett. 2015 Feb 15;25(4):960-2.

PMID: 25592708

Abstract:

Bioactivity-guided fractionation of the MeOH extract from the roots of Sophora tonkinensis resulted in the isolation of a new pterocarpan glycoside (1) together with nine known compounds, maackiain (2), sophoranone (3), sophoranochromene (4), pinoresinol (5), syringaresinol (6), medioresinol (7), 4',7-dihydroxyflavone (8), calycosin (9), and genistein (10). The structure of the new compound was determined on the basis of spectroscopic analysis including NMR and CD data in combination with acid hydrolysis. Compounds 1-4 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 13.6 to 33.0μM in RAW 264.7 macrophages.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP23057558 (−)-Sophoranone (−)-Sophoranone 23057-55-8 Price
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