Home
Resources
Publications
Inhibitory Effect of Desoxyrhaponticin and Rhaponticin, Two Natural Stilbene Glycosides From the Tibetan Nutritional Food Rheum Tanguticum Maxim. Ex Balf., on Fatty Acid Synthase and Human Breast Cancer Cells

Inhibitory Effect of Desoxyrhaponticin and Rhaponticin, Two Natural Stilbene Glycosides From the Tibetan Nutritional Food Rheum Tanguticum Maxim. Ex Balf., on Fatty Acid Synthase and Human Breast Cancer Cells

Ping Li, Weixi Tian, Xiaoyan Wang, Xiaofeng Ma

Food Funct. 2014 Feb;5(2):251-6.

PMID: 24362821

Abstract:

Fatty acid synthase (FAS) has attracted more and more attention as a potential target for cancer treatment. Natural FAS inhibitors are emerging as potential therapeutic agents to treat cancer. Rheum tanguticum Maxim. ex Balf. (rhubarb) is a traditional Chinese nutritional food and has been reported to possess a variety of biological activities, including the ability to induce the apoptosis of cancer cells. This study indicates that desoxyrhaponticin (DC) and rhaponticin (RC), two stilbene glycosides from rhubarb, could be considered as promising FAS inhibitors. We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. In addition, the apoptotic effect of DC on human cancer cells was announced for the first time. Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP30197149	Desoxyrhaponticin		30197-14-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: